Educational rheumatology content for clinicians — daily digest entries, cases, and learning modules by Dr. Sree Hari Reddy MD.
Clinical conditions associated with a high ANA titer in non-autoimmune individuals
In a 28,781-patient EMR phenome-wide study, a high ANA titer (≥1:640) without autoimmune disease was strongly enriched for non-AI liver disease (NAFLD/NASH, alcohol-related) and metabolic comorbidity — broadening the differential for an unexplained high-titer ANA beyond the usual autoimmune workup.
Cellular therapies for rheumatic disease
CD19 CAR-T cellular therapy delivers drug-free remission in 80–85% of refractory SLE patients in early-phase trials, with similar signals in IIM and SSc — the first credible attempt at true immunological reset in autoimmune rheumatic disease.
Welcome to Rheumatology Digest
A new permanent home for Rheumatology Digest — daily clinical write-ups, cases, quizzes, and learning modules.